Validation study on the Ocular Irritection® assay for eye irritation testing

Alternative methods for the replacement of eye irritation testing.

In the last decades significant regulatory attempts were made to replace, refine and reduce animal testing to assess the risk of consumer products for the human eye. As the original in vivo Draize eye test has been criticized for limited predictivity, costs and ethical issues, several animal-free test methods have been developed to categorize substances according to the global harmonized system...

In vitro alternatives for ocular irritation.

The necessity of using animals to test whether new chemicals and products are eye irritants has been questioned with increasing frequency and fervor over the last 20 years. During this time many new nonanimal methods have been proposed as reliable alternatives to the traditional rabbit (Draize) test. To date, however, none of these nonanimal (in vitro) tests have become universally accepted as ...

developing a pattern based on speech acts and language functions for developing materials for the course “ the study of islamic texts translation”

هدف پژوهش حاضر ارائه ی الگویی بر اساس کنش گفتار و کارکرد زبان برای تدوین مطالب درس "بررسی آثار ترجمه شده ی اسلامی" می باشد. در الگوی جدید، جهت تدوین مطالب بهتر و جذاب تر، بر خلاف کتاب-های موجود، از مدل های سطوح گفتارِ آستین (1962)، گروه بندی عملکردهای گفتارِ سرل (1976) و کارکرد زبانیِ هالیدی (1978) بهره جسته شده است. برای این منظور، 57 آیه ی شریفه، به صورت تصادفی از بخش-های مختلف قرآن انتخاب گردید...

1 Subgroup 3 . Eye Irritation

THE PROTECTIVE EFFECT OF INDOMETHACINE ON SULFUR MUSTARD-INDUCED OCULAR DAMAGE IN THE RABBIT EYE

Sulfur mustard, a bifunctional alkylating agent, causes severe eye injury. The injury is a result of late inflammation, which is mediated by prostaglandins. Theoretically, inhibition of prostaglandins by reagents such as indomethacine could result in alleviation of clinical adverse effects. In this study, the protective effect of topically applied indomethacine against sulfur mustard toxici...